By Sharma S Prabhakar
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Extra info for An update on glomerulopathies : clinical and treatment aspects
1 Anticoagulation Use of anticoagulation in nephrotic syndrome is controversial issue. Nephrotic syndrome (NS) is associated with high risk of for thromboembolic complications, including deep venous thrombosis, renal vein thrombosis, and pulmonary embolism; this risk seems to be greater for IMN especially in patient with low albumin and previous history of thromboembolic disease. Analyses showed that in patients with IMN the benefits of oral 20 An Update on Glomerulopathies – Clinical and Treatment Aspects anticoagulation outweigh the risks.
Nephrology 2007; 12, 576–581 Chen A, Frank R, VentoS, Crosby V, Chandra M,Gauthier B, Valderrama E and Trachtman H Idiopathic membranous nephropathy in pediatric patients: presentation, response to therapy, and long-term outcome. G , Branten AJ, Wetzels JF. Idiopathic Membranous Nephropathy: Outline and Rationaleof a Treatment Strategy. American Journal of Kidney Diseases, Vol 46, No 6 (December), 2005: pp 1012-1029. Dusso B, Morange S, Burtey S. American Journal of Kidney Diseases, Vol 52, No 4 (October), 2008: pp 699-705 Ehrenreich T, Churg J.
Endothelial tubuloreticular inclusions are identified in over 90% of patients with HIVinfection collapsing glomerulopathy and interferon therapy, whereas only in 10% cases with idiopathic collapsing glomerulopathy. Besides these conditions endothelial tubuloreticular inclusions are seen commonly in systemic lupus erythematosus nephritis. Fig. 3. A glomerulus displays collapsing variant of FSGS , glomerular capillaries show collapse with absent lumen (H&E, 40X). Focal Segmental Glomerulosclerosis 35 IF microscopy of collapsing lesions often is positive for IgM and C3.