Advances in Clinical Chemistry, Vol. 4 by Harry ed. Sobotka

By Harry ed. Sobotka

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Amino acids, fatty acids, sterols, steroids, and the tricarboxylic acid cycIe. Specific enzymes catalyze each conversion indicated by arrows. Broken arrows indicate that several steps are involved. Abbreviations used: Gal-1-P, galactose-1-phosphate; UDPG, uridine diphosphate glucose; G-1-P, glucose-1-phosphate; G-6-P, glucose-6-phosphate; F-6-P, fructose-6phosphate; F-1,6-P, fructose-1,6-diphosphate; G-3-P, glyceraldehyde-%phosphate; DHAP, dihydroxyacetone phosphate; F-1-P, fructose-1-phosphate; 6-PG, 6-phosphogluconic acid; R-5-P, ribulose-5-phosphate; S-7-P, sedoheptulose-7-phosphate.

Urinary pentose increases in response to fever and during allergic responses (T4). Orr and Minot (01)reported increased urinary excretion, by patients with muscular dystrophy, of a compound which they believed to be ribose5-phosphate. Others have not been able to confirm this observation; however, Tower (T4) found that ribose excretion in patients with muscular dystrophy tended to be somewhat higher than that in normal individuals. Increased excretion of ribose has also been reported in the urine of patients with neoplasia (L7).

The point of origin of the glucuronic acid cycle from UDPG is indicated (see Fig. , amino acids, fatty acids, sterols, steroids, and the tricarboxylic acid cycIe. Specific enzymes catalyze each conversion indicated by arrows. Broken arrows indicate that several steps are involved. Abbreviations used: Gal-1-P, galactose-1-phosphate; UDPG, uridine diphosphate glucose; G-1-P, glucose-1-phosphate; G-6-P, glucose-6-phosphate; F-6-P, fructose-6phosphate; F-1,6-P, fructose-1,6-diphosphate; G-3-P, glyceraldehyde-%phosphate; DHAP, dihydroxyacetone phosphate; F-1-P, fructose-1-phosphate; 6-PG, 6-phosphogluconic acid; R-5-P, ribulose-5-phosphate; S-7-P, sedoheptulose-7-phosphate.

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