By John S. Bradley MD, John D. Nelson MD Emeritus
Read or Download 2010-2011 Nelson's Pocket Book of Pediatric Antimicrobial Therapy PDF
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Extra resources for 2010-2011 Nelson's Pocket Book of Pediatric Antimicrobial Therapy
Pharyngitis with internal ceftriaxone 100 mg/kg/day q24h AND metronidazole Metastatic and recurrent abscesses often develop while jugular vein septic thrombosis, 40 mg/kg/day div q8h or clindamycin 40 mg/kg/day on active, appropriate therapy, requiring multiple postanginal sepsis, div q6h (BIII) debridements and prolonged antibiotic therapy. 87 mL in Susp Structured Vehicle USNF)(CIII) Start treatment as soon as oral intake compromised. Consider adding amox/clav or clindamycin for severe disease with oral flora superinfection.
5 mg/kg/day IM (AIII) effective: cefepime IV, meropenem IV or imipenem IV, pip/tazo Otitis externa – Bacterial (swimmer’s ear) Topical antibiotics: fluoroquinolone (ciprofloxacin or Wick moistened with Burow solution used for marked (P aeruginosa, S aureus, ofloxacin) with steroid, OR neomycin/polymyxin B/ swelling of canal; to prevent swimmer’s ear, 2% acetic 61,62 including CA-MRSA) hydrocortisone (BII) acid to canal after water exposure will restore acid pH Irrigation and cleaning canal of detritus important Bullous myringitis (see Otitis media, acute) D.
Cephalosporins, nafcillin, oxacillin, and clindamycin penetrate poorly (10%–15%), and fetal concentrations of erythromycin and dicloxacillin are less than 10% of those in the mother. The use of antimicrobials by the mother during breastfeeding should be balanced by the risk of clinical or laboratory toxicities in the infant. In general, the neonatal exposure is welltolerated. While maternal treatment with sulfa-containing antibiotics should be approached with caution in the breastfed jaundiced or ill neonate, no symptoms have been associated with maternal treatment with amoxicillin, cefazolin, cefotaxime, ceftazidime, ceftriaxone, ciprofloxacin, clindamycin, erythromycin, ethambutol, fluconazole, gentamicin, isoniazid, rifampin, (used for <3 weeks).